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The repeatability coefficients were calculated with the analysis of variance.

The predictive values of the different variables (APOE4, memory tests and brain metabolite values) were calculated with the analysis of receiver operating characteristic (ROC) curves.

Twenty six patients in each group (power of 80% and type I error of 5%) was calculated with the analysis using sample size software (PASS 2005®, NCSS, USA).

Importantly for their broad applicability, indices such as RTB/HIV can be calculated with the joint analysis of data that are gathered regularly and independently by monitoring agencies.

The test-retest reliability was analyzed by using the type 2.1 interclass correlation coefficient, and the error sensitivity was calculated with the MDC95 analysis of Stratford.

Confirmatory statistics was based on 2-sided t-tests for two independent samples calculated with the parameter estimates of an analysis of covariance (ANCOVA), using the primary parameter as dependent variable, the treatment group (with two levels) and centre as fixed factors, and the baseline MMP-9 value as covariate.

Average lesion area was calculated with the aid of imaging analysis software.

Two shape factors calculated with the results of image analysis, circularity and projected area equivalent diameter (Heywood diameter), as well as span value for size distribution, were chosen as responses for analyses of variance.

The LC50 value of copperoxychloride was calculated with the help of probit analysis using SPSS software (SPSS for Windows 14.0; SPSS Inc., Chicago, IL, USA, 2005).

The images were reconstructed with the B36f kernel (b36f), and CACS was calculated with the use of CAC analysis software (Cascore, Siemens, Germany) using the Agatstone method [ 16].

*p values were calculated with the use of logistic-regression analysis.