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To compare model fit the mean absolute error and the root mean squared error were calculated, with tests for significance using Student's t-test with a p-value of 0.05.
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Simple group differences were calculated with t-tests.
P-values for testing differences between proportions were calculated with χ tests or with Fischer's exact tests.
Statistical analysis Comparisons between treatment groups were calculated with t tests or Wilcoxon rank-sum tests when appropriate.
P values for testing differences between proportions and response rates were calculated with χ tests for homogeneity or for trend, or with Fisher's exact test.
The differences of haplotype frequencies were calculated with χ-tests and permutation tests.
Comparison between conditions within groups was calculated with Friedman tests for multiple related samples and post-hoc comparisons.
*P values calculated with Χ2 tests.
Univariate comparisons between groups were calculated with median tests.
The odds ratios (OR), 95% confidence intervals (CI) and P values were calculated with exact tests for categorical data.
Correlations between variables were calculated with Spearman test.
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