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Relative quantification of gene expression was calculated via the comparative threshold cycle (ddCt) method63.

The final porosity of the scaffolds was calculated via the following equation: porosity  = (W3 − W1)/(W3 − W2) × 100%.

Severity of illness is based on a score calculated via blood tests that show how far the disease has progressed.

Changes in expression were calculated via the ΔΔCt method.

The failure rate and repair rate is calculated via Eqs.

ANOVA was calculated via StatView 5.0.1 software.

All analyses were calculated via SAS statistical software.

Prior probabilities were calculated via group sizes.

Maximum likelihood was calculated via simulated annealing.

From this, 𝒵 can be calculated via a simple traversal.

Weights can be calculated via the right eigenvector.

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