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Actual ET was measured with weighing lysimeters and used to correct equilibrium ET, calculated using the Priestley-Taylor combination method.

The standard errors for elasticity ε l,w are based on the delta method and calculated using the non-linear combination program "nlcom".

The CIR was calculated using the IFFT in combination with a Blackman window (see Figure 11) applied to all 801 frequency response points.

The joint gene P value was calculated using the Fisher's combination test as described by Peng et al. (2010).

SDRs were calculated using the PRR in combination with Chi (with Yates correction) with a signal threshold of number of cases (N) ≥3, PRR ≥ 2 and Chi ≥ 4, as described by Evans et al. [ 2].

Seven spectral indices (Table 2) were calculated using the different spectral band combinations.

Ds and ADCs calculated using the different b value combinations were compared using the non-parametric Wilcoxon signed-rank test.

The differences between median and mean ADCs were found to be to the same order as the differences between ADCs calculated using the different b value combinations (B0 B5).

The combination index was calculated using the formula %AB/%A × %B, as described under "Methods".

Drug combination effects were estimated based on the combination index (CI) values calculated using the CalcuSyn software (Biosoft, Ferguson, MO, USA).

The combined effect of PMA and apicularen A (combination index) was calculated using the formula %AB/%A × %B, where A and B are the effects of each individual agent and AB is the effect of the combination.

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