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Sample size was calculated using a Raosoft sample size calculator.

Genetic distances were calculated using a Kimura 2 parameter method.

Significance is calculated using a Cox proportional hazards model.

Linkage disequilibrium was calculated using a custom written python script.

Vector-flow maps were calculated using a multi-angle Doppler estimation strategy36.

Post-hoc pairwise comparisons were calculated using a sequential Bonferroni correction to adjust p-values.

Statistical significance was calculated using (a) simple Mann Whitney or (c f) one-way ANOVA tests.

p-values were calculated using a two tailed, unpaired t-test with unequal variances.

Tracer concentration was calculated using a standard curve and normalized to matched controls (set to 1).

Protein concentration was calculated using a BCA assay (Pierce) following the manufacturer's protocol.

Weekly alcohol consumption was calculated using a method reported in a previous study60.

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