Note that this number is much lower than the value of R e = 1.06 we calculated for this timeframe, which is unsurprising in view of the fact that many of our networks only provide a sample of all infections.
Results were calculated for two timeframes: from day 1 postpartum until day 28 postpartum (CLA supplemented period) and from day 29 postpartum until day 56 postpartum.
Since such measures assume all dispensed medication is used as directed, they have a built in upward bias that is especially pronounced when they are calculated over relatively short timeframes (< 9 months).
From a cost-consequence model with a 1-year timeframe, the sponsor calculated the device would reduce electrocardiogram (ECG) referrals and prevent strokes, but incur anticoagulation therapy costs, with net NHS savings of £11.6 million and prevention of 221 strokes, annually.
Hence, all subsequently calculated probabilities should be understood within this timeframe, i.e. they represent the probability for at least one event occurring within the next month.
The expected maximum ash load for timeframes of interest is also calculated.
Thereby, in order to decide which event occurs and ends the treatment, the time of each event is calculated separately and the event with the shortest timeframe is taken into account.
For each outcome we calculated the proportion of patients treated within these timeframes by year and then plotted the 2008-09 rates of all hospital trust separately using funnel plots with 99.8% control limits to identify statistical outliers.
Likewise, to adjust for variations in data availability timeframes across individuals, admission rates were calculated as admission days per year.
Because all global warming potentials (GWPs) are calculated relative to CO2, GWPs based on a shorter timeframe are larger for gases with shorter lifetimes than that of CO2.
Costs and outcomes were calculated separately for each treatment alternative over the model timeframe and then discounted at 3.5 % per annum [ 25].
