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Optical mapping is inherently noisy, small fragments are detected inefficiently, and fragment sizes are calculated imprecisely (OpGen, Inc., personal communication).
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Another limitation is that HIV incidence estimates calculated by the CDC method involve several imprecisely estimated inputs.
"They calculated".
Nothing's calculated like — calculated.
As calculated.
Calculated risks.
Be calculated.
Everything was calculated".
She's VERY calculated.
And very calculated.
The observation scheme aims to estimate the imprecisely known parameter based on the available measurement.
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