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The average study duration was calculated from study start and study completion dates.
Time to progression was calculated from study entry to documented disease progression.
Time to death was calculated from study entry to death or last follow-up.
Where necessary, and feasible, the mean age of participants was calculated from study data [ 8, 71- 74].
Progression-free survival (PFS) was calculated from study entry to documented disease progression or death from any cause, whichever occurred first.
In the mortality analysis, person-time was calculated from study entry date to date of death, termination of health insurance coverage, or 31 December 2007.
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The intensity of the peak lies in the right range to be produced by dark matter reactions, the researchers say: higher than a lower limit inferred from the galaxy cluster data, but lower than a ceiling calculated from studies of the Milky Way's less dense outer regions.
Seven were calculated from studies that presented each groups' mean change in mental health score from baseline to follow-up.
To estimate the number of diarrhea cases in each setting that are attributable to rotavirus, we applied proportions calculated from studies of rotavirus in children in developing countries.
32 Mortality associated with multidrug resistant UTI and with bacteraemia were calculated from studies by Klevens et al 2008 33 and Montgomerie 2011, 34 respectively.
However, the PAFs were calculated from studies including a very large-scale population-based prospective study with over 1 million subjects, therefore we believe that the degree of uncertainty in our RR and PAF estimation was reduced.
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