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The calculated end point postponement values are given in table 1, together with the effect measures provided in the original publications.
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The measured stable pressure drop(s) and the corresponding flow rate(s) were used to calculate end-point water permeability to water (krw Sor using Darcy's law.
The average specific growth rate was calculated as end point according to OECD 201.
The proportion of immobilized in relation to inserted D. magna after 48 h exposure was calculated as end point according to OECD 202.
What is tricky is the second equality that that integral is the difference in a function calculated at one end point minus the other end point.
The study sample size is calculated towards primary end point.
The BMD10 values calculated for each end point are presented in Table 4.
Estimated means for US and EU groups were calculated for each end point and each treatment arm based on the model described above.
Estimated (or predicted) means were calculated for each end point and for each treatment, as estimated using the repeated-measures mixed-effects model (MM), controlling for time, treatment, country, treatment-by-time, and treatment-by-country interactions, and baseline (cycle 1, day 1) score (Fairclough, 2002; Singer and Willett, 2003; Fitzmaurice et al, 2004).
The number of patients included in the chronic pain calculation differed from the 951 patients identified for calculating the primary end point.
The primary analytic sample (PAS) included all patients with data available to calculate the primary end point (IRLOS).
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