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The risk ratio was 1.2 (95% CI 0.9 1.6) when we calculated duration based on time between prescriptions and 1.6 (1.0 2.4) when we calculated duration by summing days supply for each prescription.
When hormonal contraception was switched without pause, we calculated duration as the sum of use before switch and current use of the new preparation.
We also measured Pulses, and calculated Duration as the distance between the onset of the first pulse and the end of the last one.
In order to estimate the accuracy of the presentation timing, we compared the actual stimulus duration measured using the photosensitive diode with (1) the duration set by the experimenter and (2) the calculated duration logged in the QRTE data file.
Where patients had not responded to the question about duration of symptoms, we calculated duration from dates provided by the patient, if they had given day, month and year for both onset of symptoms and date of seeing a doctor.
23 We also included use of immunosuppressive treatment; we extracted all relevant prescriptions before the index date and calculated duration of prescription (using data on quantity of tablets prescribed and numeric daily dose).
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An in-house C++ program was used to calculate duration of sleep in minutes, numbers of sleep bouts, average sleep bout duration in minutes, and the number of activity counts per waking minute-waking activity.
The model makes it possible to predict sweat rate and core temperature and calculate duration exposure limits (29– 31).
For one patient no data regarding root pain were recorded, for another a report of root pain was given but no date to calculate duration of pain.
Furthermore, our questionnaire data lacked the level of detail to calculate duration or intensity of daycare exposure; therefore, this study could not evaluate a dose-response relationship between amount of time in daycare and risk of developing T1D.
Computer software will be used to calculate duration, amplitude and impulse of the reaction forces; Knee adduction moment (KAM) is considered a valid parameter to infer the level of mechanical loading [ 122].
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