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VO2, whether calculated by spirometry, indirect calorimetry, or using a PAC, is similar to the plateau of VO2 in the VO2/DO2 relationship.
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ΔEELV after a PEEP step was calculated by direct spirometry, which was shown to be a robust method compared with functional residual capacity measured by a washin/washout method with insoluble gases [ 14].
Percent-predicted values were calculated by taking the ratio of observed spirometry measurements over predicted values and multiplying by 100%.
Both FEV1 and FVC were measured and used to calculate FEV1/FVC ratios in addition to %VC using the method proposed by Baldwin et al. 9 The mean annual change in spirometry data was calculated by subtracting the follow-up results from the initial evaluation results and dividing by the number of years between initial evaluation and follow-up.
Only raw PFT data were provided and % predicted values were subsequently calculated by a single investigator (CD2) for the whole population according to Stanojevic for spirometry [ 9] and other international recommendations for DLCO and static lung volumes respectively [ 10, 11].
We calculated the best spirometry values for analysis by averaging the measures from the two maneuvers with the first and second greatest FVC.
The BMI was re-calculated at every spirometry.
Lung function was determined by spirometry, and post-bronchodilator forced expiratory volume in 1 sec (FEV1) and forced vital capacity (FVC) were calculated from the flow-volume curve, and FEV1/FVC was calculated.
Inflammation biomarkers were measured in sputum by ELISA and the lung function was evaluated by spirometry.
The severity of airflow obstruction was assessed by spirometry.
It is evaluated by spirometry, CT scanning, and bronchoscopy with significant limitations.
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