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Throughout the manuscript, transition rate (transitions per bp) was calculated by totaling the number of cryptic initiations that are calculated at defined cutoffs for a particular class of genes and then dividing this number by the total length of genes analyzed within that class.

In addition, sensitivity and specificity (with 95% confidence interval) was calculated at defined cut-off VEGF levels for detecting insufficient therapeutic efficacy and progression.

We calculated an Action Threshold (AT), defined as the maximum acceptable discrepancy between the dose measured with the detector and the dose calculated with the TPS for each single field from phantom data [ 12].

The electrostatic potential (ESP) was calculated at a set of gridpoints defining the molecular surface in the solvent-accessible region around each optimized conformation at 1.4, 1.6, 1.8, and 2.0 times the vdw radii using the program DMS at a density of 0.5, yielding 2.5 2.8 points/Å.

The dose was calculated at the reference isodose, defined as 85% of the basal dose calculated in the central plane of application.

Obese-years was calculated at each examination as the defined level of obesity (in 'obese units') multiplied by the defined duration of obesity (in years).

We train the RF classifier using 27 features (defined below) calculated at each pixel.

*Organ failure free days, organ dysfunction free days, and vasoactive drug free days are calculated at day 14; Organ dysfunction was defined by a sequential organ failure assessment (SOFA) score above one for the appropriate function; Organ failure was defined by a SOFA score above two for the appropriate function.

The simulation performance parameters are as follows: Throughput: one of the performance metrics that should be calculated at each sink node and is defined as the number of the packets successfully received at the sink node divided by the total number of the packets sent to the sink node including any retransmissions.

Maternal BMI (kg/m) was calculated at the first obstetrical visit and defined as <25 kg/m normal BMI (NBMI), overweight (OW) 25 29.9 kg/m, and obese (OB) ≥30 kg/m.

The chlamydia positivity was also calculated and defined as the proportion of patients tested with at least one positive test.