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The C-PIB retention data were calculated as standard uptake values as previously described in detail (Klunk et al., 2004) and were obtained in a late time interval (40 60 min).
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All reported error estimates were calculated as standard error.
The standard deviation of S is calculated as: Standard deviation (S) = √((R2/ n-2)) +1/var (d)).
Following [46], the standard deviation of R is calculated as: Standard deviation (R) = √(R2/ n-2)).
The standard deviation of E is calculated as: Standard deviation (E) = √(1/var (d)).
Error was calculated as standard deviation.
The uptake of radiotracers in the tumours was calculated as a standard uptake value (SUV) [38] in which the regional activity is related to the total injected dose and normalised to standardise for between-individual comparisons.
Cortical C-Pittsburgh compound B values were calculated as a standard uptake value ratio normalized to cerebellum grey/white matter.
The distribution data are expressed in %ID or are normalized to the BW as standard uptake value (SUV), which was calculated with the formula: SUV = (activity per g tissue)/(injected activity) × BW.
Values are expressed as Standard uptake values with cerebellum uptake as reference (SUVR).
Because the delivered dose of radiation is calculated by the standard uptake value, the differences in FDG PET uptake have implications for determining the radiation dose at different sites following F-FDG therapy.
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