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Coefficient of variation (CV) was calculated as standard deviation/mean and expressed as percentage.
The coefficient of variation of P cuff was calculated as standard deviation/mean P cuff × 100.
Two responses; particle size (PS, measured by SEM) and particle-size distribution (PSD, calculated as standard deviation, ±SD) were measured.
The identifiability of kinetic variables was expressed as a percentage of the rate constant and calculated as standard error obtained from the diagonal of the covariance matrix [24].
The identifiability of kinetic variables was calculated as standard error obtained from the diagonal of the covariance matrix [17] and expressed as a percentage of the rate constant.
Between-animal variability was measured as the COV, calculated as standard error of the estimate divided by the estimate, and expressed as a percentage.
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Then the average intensity per segment is calculated, as well as the standard deviation.
The difference of the means was calculated as well as the standard deviation of the difference.
The coefficient of variation (CV) was calculated for as standard deviation / mean amplitude of individual evoked EPSCs and expressed as 1/CV2.
The standard error of each proportion was calculated as follows; standard error = √p 1-p /n), where p is proportion and n is sample size.
The lower limit of quantification (LLOQ) was calculated as two standard deviations above the levels measured in the zero samples on the standard curve.
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