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EC50 values were calculated as published [60].
The EC50 and CC50 values were calculated as published [66].
SOFA score was calculated as published with a few modifications.
DMF-T index was calculated as published previously by Baume [ 14].
Glucose area under the curve (AUC) was calculated as published elsewhere (13).
The PedACR30 and the PedACR70 scores were calculated as published [ 32].
Similar(51)
Lactate clearance was calculated as previously published [ 15]: (lactateT0–lactateTx) · lactateT0−1 · 100%%.
Body mass index was calculated as previously published.
First, we used an estimation of life expectancy for survivors to enable cost-utility over a lifetime horizon to be calculated, as previously published [ 10, 19].
Glucose data available until earlier of 48 hours after cessation of mechanical ventilation or day 12. Days without organ failure until day 28 calculated as previously published.
A staining index (values 0 9), obtained as a product of staining intensity (0 3) and proportion of immunopositive tumour cells (⩽10%=1, 10 50%=2, >50%=3), was calculated as previously published (Aas et al, 1996; Straume and Akslen, 1997).
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