However, when the areas under the curves (AUC) during the time course were calculated, a dose dependent effect of RWJ-67657 on Ang-2 release was present.
These data, along with modelling and simulations, were used to calculate a fixed dose of 600 mg for use in phase III trials to further investigate the safety and efficacy of trastuzumab SC (Wynne et al, 2013).
For BPA, the lowest dose studied for risk assessment purposes was 50 mg/kg/day, which is the currently accepted lowest observed adverse effect level (LOAEL) that was used to calculate a reference dose of 50 μg/kg/day based on experiments conducted in the 1980s IRIS 19888).
The drug cost is calculated at a dose of 1.5 mg per kilogram (kg) of body weight administered three times daily.
Cholesterol assimilated by each Lactobacillus strain was calculated considering a dose of 10 cells: (3) cholesterol assimilated (mg / mL ) probiotic cell viability (cfu / mL ) × 10 10.
Previously, we calculated that a dose of 15 J/m would result in ∼35 closely opposed (≤75 bp) pairs of lesions, assuming a random distribution (Yin and Petes 2013).
For the CT protocol applied by Nijkeuter et al. [59] we calculated a breast dose of 11 mGy or 1.32 mSv respectively, associated with a 0.017 mGy fetal dose in the first trimester.
Using a second-degree polynomial model, we calculated a benchmark dose of 3 mg/kg/day, with a lower bound (95% confidence limit) of 1.75 mg/kg/day.
As a base to calculate a reference dose, or maximum acceptable dose of a toxic substance, the NRC recommended adding an uncertainty factor of 10 to this estimate, because of biological variability and inadequate data [ 11].
The present findings are very similar to the results of a preliminary study [16] that calculated an effective dose of 19.3 ±1.30 μSv/MBq in three subjects from an Asian population and evaluated the organ kinetics over a shorter (3 h) time period.
