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Variance in W168 was higher in the RAS group, when compared to BFT and cage groups.
The mean CT scores of three groups were 33.3 points, 35.0 points, and 33.6 points in AIB, CFC, and F-u-HA/PLLA cage groups, respectively (full-score: 56 points).
These cage groups were maintained throughout the experiments.
In the no handling groups, there were significantly higher levels of activity in the playground groups compared to the home cage groups, irrespective of genotype and sex (F 1,143) = 125.438, p<0.001; Figure 7A).
In the home cage groups, handling had no effect on the age at death in male mice, but had a beneficial effect in female mice (p = 0.001; Table 2).
A similar negative effect of handling on body weight for was found for male R6/2 mice in the home cage groups between 9 and 16 weeks of age (p = 0.024; Figure 9A) but not in the playground groups (Figure 9C).
Similar(35)
'Caged' compounds are biological molecules that are rendered inactive by a protecting (cage) group.
A similar period of a home cage group was also recorded.
The rats in each cage group were allocated to 1 of 2 different diets, matched for micro- and macronutrients, but with a different amylaceous fraction and, therefore, different GI in a 2 × 2 factorial design.
Then, food consumption of each cage group was recorded by weighing of the food hopper over a period of 4 hrs.
There was no difference in the increase in handling needed between R6/2 groups, but WT playground mice showed a greater increase in handling needed than the home cage group (p = 0.003, Figure 8D).
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