The A allele in eotaxin 67 G/A polymorphism is associated with worse survival in CAD patients.
Societal and demographic changes, including aging of the general population and improved survival from CAD, will increase HF prevalence with a potential doubling in HF prevalence within the next 40 years [ 2].
Survival curves stratified according to P-cad expression are illustrated in Fig 3. Still in terms of overall survival, within P-cad +ve group, OSCCs (n = 12) with a prevalent citoplasmic pattern of P-cad showed poorer survival rates than those (n = 25) with a prevalent membranous P-cad expression (P <0.0001).
In terms of prognostic significance, P-cad non expression was found to have an independent association with poorer overall survival rate than P-cad expressing group (P = 0.056); moreover, among P-cad +ve patients the best prognosis was for those OSCC with membranous (P < 0.0001) than those with cytoplasmic P-cad expression.
Hence, in terms of prognostic significance, the lack of P-cad expression (44.8%) was found to have an independent association with poorer overall survival rate than P-cad expressing group; moreover, the abnormal (cytoplasmic) expression of P-cad is also associated to a poorer prognosis when compared to that normally membranous.
We have previously shown that selection of donor hearts older than 40 years of age based on coronary angiography to exclude pre-existing CAD did not reduce the prevalence of CAD nor improved survival among heart recipients between 1988 and 2005 [ 32].
Importantly, our patients without CAD had a 100% event-free survival at mid-term follow-up.
Being an independent predictor of morbidity and mortality, this improvement of endothelial function may serve as surrogate evidence for improved survival of patients with CAD as a result of new secondary prevention guidelines.
A dose-response relationship has been reported between attendance to outpatient CR and long-term survival in elderly individuals CAD [ 31], suggesting that attendance to outpatient CR may be a proxy for other factors including health status [ 32].
Additionally, although neighbourhood unemployment is associated with presence of CAD [12], effects of neighbourhood unemployment on survival in CAD patients have not yet been adequately characterized.
