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When compared with control subjects, RA patients did not exhibit greater total CaSR (101.6% ± 28.8 vs. 99.9% ± 22.0) or surface CaSR (104.6% ± 20.4 vs. 99.9% ± 13.7) expression, but total CaSR expression in circulating monocytes was significantly higher in RA patients with severe CAC (Agatston score ≥200, n = 11) than in patients with mild-to-moderate CAC (1 to 199, n = 21) (P = 0.01).
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Speculating that total and surface CaSR expression in human circulating monocytes could be different between RA patients with mild-to-moderate or severe coronary artery calcification (CAC = 1 to 199 versus CAC ≥200 or CAC = 30 to 199 versus CAC ≥200 with a limit of detection for CAC set at 30 instead of 0), subgroup analysis was also performed.
The risk of mortality increased with increasing levels of CAC, plateauing at approximately CAC ≥1,000 (2.7% annual mortality).
In a study of 510 asymptomatic T2DM subjects from West London, the adjusted risk for CVD events during a mean follow-up of 2.2 (SD 0.4) years was 58.05 955% CI 12.28 274.48) among participants with CAC ≥1,000 compared with participants with no CAC (24).
The investigators found an increased risk of all-cause mortality in patients with diabetes with higher CAC scores with an OR (95% CI) of 5.76 (4.61–10.39) in CAC ≥1,000 compared with CAC 0 10, which are similar to our findings and a comparable mortality between patients with diabetes with no calcium and nondiabetic subjects.
The CAC 40 in France closed unchanged.
The CAC 40 in Paris declined 0.53 percent.
The CAC 40 in France gained 4.1 percent.
The CAC 40 of France fell 1.5 percent.
In Paris, the CAC 40 rose 0.6 percent.
France's CAC 40 dropped 0.48 percent.
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