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Each chain is composed of a variable (V) region and a constant (C) region.
(c) Region with increased maternal mutation rate on chromosome 9 (chr9: 0-10,000,000).
In the past, selection of the constant region (C region) for therapeutic mAbs was based on knowledge retrieved from in vitro analysis of effector functions such as phagocytosis, induction of inflammatory cytokines or chemokines, and antibody-dependent cellular cytoxicity (ADCC).
Asterisks indicate Bonferonni-corrected comparisons at P<0.05 for both A and B. (c) Region of interest analysis with ventral striatum (VS) demonstrating a significant association between anti-anhedonic response to ketamine and increased glucose metabolism in the VS.
c Region detector.
c Region detection.
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a, c Region-of-interest time-activity curves of control rats.
b, ORCA data at 10-kb resolution for the 330-kb BX-C region, normalized as in Fig. 4, for cells from segment A1 in wild-type and Fub mutant embryos.
Polytene chromosome analysis revealed a deletion of the 51A-C region.
MAbs HGW17 and HGY25 were provisionally assigned to the C-C region since they competed with 3D6.
Twenty-one mAboundund to gp41 by targeting primarily the immunodominant C-C region, the HR-1 and the region recognized by 5F3 mAb [64] (Table 2).
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