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These results suggest that mitochondrial calcium uptake and the activation of mtNOS might be an important event in producing bystander factor(s).
However, recently exosomes have emerged as a possible candidate for the bystander "factor" signaling in the MCF7 (Al-Mayah et al. 2012) and HaCaT cell lines (Jella et al. 2014).
One experiment in particular revealed that bystander signals can be passed from irradiated rainbow trout (Oncorhynchus mykiss) to neighboring nonirradiated fish, via release of a chemical component into the water surrounding the fish, indicative of bystander factor(s) (Mothersill et al. 2006).
Treatment with anti-oxidant substances, L -lactate and L -deprenyl prevented bystander factor associated cell kill.
The bystander factor is still unknown, and the specific molecular events and signaling entities are still not completely understood.
These observations, together with the findings that ruthenium red treatment significantly reduced the NO and O2− levels in irradiated ρ+ AL cells, suggest that radiation-induced NO derived from mitochondria might be an intracellular bystander factor and calcium-dependent mitochondrial NOS might play an essential role in the process.
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Additional studies showed that elevated NaCl made the non-irradiated bystander cells more vulnerable to bystander factors.
The results show that the CpG-to-gene ratio of the HCNE enriched ST miRNAs is significantly higher than those of bystander, transcription factor and CGI-associated genes, while there is no significant difference in the comparison with the GRB target genes (Table 2).
Our previous studies have shown that TGF-β1 is an important t bystander signaling factor which can further raise the level of intracellular ROS and NO and then cause DNA damage [ 49, 50].
This result suggests that the TGF- β1 signalling pathway in bystander cells could be activated by bystander signalling factors in RCM, thereby mediating RIBEs.
The bystander effect factors strongly in Joe Cinque's death.
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