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This pattern could indicate a primary role in mediating this stage of progression or a bystander event associated with a change in the requirement for this protein.
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Whether these relationships are linked causally or represent bystander events remains unknown.
However, sometimes they may simply represent bystander events of negligible significance.
However, most of the microsatellite mutations observed in MMR-deficient cells are bystander events that do not play a causal role in carcinogenesis.
Early differentially methylated genes may contribute to onset and progression of the disease, while the far more abundant and diverse differentially methylated genes at the late leukemic disease stage may reflect clonal diversification of AML and bystander events.
It can be proposed that radiation-induced generation of ROS is mainly responsible for direct DNA damage and the early event of bystander effect, meanwhile NO as a persistent bystander signal during cell coculture (Shao et al, 2004) is a source of integral process of bystander responses.
Thus, even though a number of possibilities can be conceived to explain pri-miR-221/222 overexpression as a bystander effect of other oncogenic events, at present none of these is sufficiently plausible to discredit the possibility that pri-miR-221/222 may itself act as an oncogene.
This is called bystander effect to signify that it is a case when a tragedy occurs because bystanders to the event fail to intervene.
The bystander effect may be a potentially harmful or a useful event in radiotherapy.
Disturbance in the process could conversely result in amplification of bystander inflammatory events [ 33].
Point mutations, copy number changes, and structural changes can all be critical events driving tumor evolution or can be bystander passenger events not contributing to the disease.
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CEO of Professional Science Editing for Scientists @ prosciediting.com