Gfi1 disruption antagonized the tumor-promoting effects of Ezh2 loss; conversely, Gfi1 overexpression collaborated with Myc to bypass effects of Trp53 inactivation in driving MB progression in primary cerebellar neuronal progenitors.
Furthermore, type III IFN signalling can similarly bypass effects of sifalimumab and induce activation of IRF-9 and transcription of IFN-inducible genes, 28 although IFN-λ induces a much smaller effect on IFNGS in blood (data not shown).
This may be due to its targeting a central downstream molecule and also due to the potential for a number of processes to bypass effects at the level of PI3K.
Inhibition of GSK3β using lithium rescues Schwann cell differentiation, bypassing the effect of plasmalogen deficiency (da Silva et al., 2014).
The dTT and ECT only measure the specific effects of antithrombin activity the former by adding exogenous thrombin to diluted plasma and the latter by activating endogenous thrombin, thus bypassing any effect of factor Xa inhibition.
By bypassing the effect of ABZ1, we identified another genetic control of the fermentation rate: the improvement of fermentation kinetics by partial disomy of the left arm of chromosome 16.
For high internal circulation rates the solids residence time distribution of the fuel reactor is dominated by the bypass effect.
McColley did take part two years ago in studies of denufosol, a drug produced by the biotech company Inspire that works in a different way from the Vertex and PTC drugs, by stimulating an alternative-chloride channel and bypassing the effects of the genetic mutations entirely.
Some of these questions may be solved through bypassing the effects associated with fluid-filled systems and measuring IAP with a balloon-tipped catheter.
