Genetic alterations and activation of bypass tracks are two main mechanisms of acquiring resistance.
In crizotinib-resistant tumors, several distinct bypass tracks mediating resistance have been reported.
An increasing recognized drug resistance mechanism occurs through a bypass tracks module.
Moreover, alternative signaling pathways, or so-called bypass tracks, can be activated in resistant cells bypassing the need for signaling from the target.
They can either be moved at night, when passenger traffic is strongly reduced or they have to draw aside onto bypass tracks when faster passenger trains are going to overtake them.
Since it is impossible to execute the whole freight traffic at night, the lengths of the bypass tracks automatically restrict train lengths (e.g., to 630 m in Denmark and 700 m in Germany).
The reviewers bring up the important point that stably acquired resistance to EGFR inhibitors can take many forms, from secondary gatekeeper mutations within EGFR, to induction of MET or other "bypass tracks", to epithelial-mesenchymal transition (EMT) and even lineage switching from non-small cell to small cell histology.
Clinical studies of acquired resistance provide clear rationales on how to develop improved strategies to prevent or overcome resistance, guiding the development of next-generation inhibitors addressing secondary target mutations, or informing new combinations aimed at co-targeting of bypass tracks.
He told police he was bypassing train tracks.
He pulled along a host of others, again, mostly from Kenya, who are racing marathons having bypassed that track pipeline.
The running across train tracks bit of this "rolling meeting" was prompted by the fact that the police kept a close eye on the overbridge that would have otherwise helped us bypass the tracks safely.
