The use of naturally derived materials that mimic healthy ECM is a promising therapeutic option and also bypasses risks associated with other treatments, such as the need for immunosuppressant drugs, induction of endogenous inflammatory responses and the difficulties associated with cell culture (Kuraitis et al., 2012b).
In the axillofemoral bypass, the risk of graft occlusion was expected to be higher in the patient who lived a sedentary lifestyle compared with the ambulatory individual.
The objective of this work is to seek proof-of-concept for the hypothesis that a single vaccine vector targeting multiple DEN virus serotypes has the potential to bypass the risk of viral interference inherent in the currently prevalent approach of mixing 'monovalent' vaccines.
Greene bypasses that risk.
The proposed rule would "effectively prohibit broker-dealers from providing" so-called naked-sponsored access, in which a customer bypasses pretrade risk controls, according to the agency's statement.
Direct sperm transfer in the form of copulation bypasses the risk of environmental damage in many more derived forms (Selden and Edwards 1990).
These reactors achieve greater safety through passive technologies that automatically shut down the reactor in an emergency, bypassing the risk of operator error (humans still control the normal operation and shutdown of these reactors).
Finally, due to the fact that some of the tested models were trained on more than 3 parameters, we applied the AIC method to detect only the significant variables bypassing the risk of overfitting (details added in the Materials and methods section, paragraph "Correlations, prediction power and cross-validation").
Overall, single protein, FMOD-based, cell reprograming bypasses the risks of mutation, gene instability, and malignancy associated with genetically-modified iPS cells, and provides an alternative strategy for engineering patient-specific multipotent cells for basic research and therapeutic application.
Preoperative percutaneous coronary intervention has unproven perioperative benefit, and coronary artery bypass graft carries risks that often offset the risk of noncardiac surgery.
Notwithstanding, even new generation drug eluting stents remained less effective than coronary artery bypass grafting for risk of subsequent revascularisation.
