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Spliced and debranched mirtrons are able to bypass processing by Drosha, and access the canonical miRNA processing pathway following nuclear export [ 12].
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Recent theories of addiction posit that relapse-inducing cues cause relapse habitually or automatically, bypassing processing information related to the consequences of relapse.
mir-62 belongs to the mirtron subclass of miRNAs, which reside in short introns of host mRNA genes, from which the uncapped pre-miRNA is released the uncapped pre-miRNAplising, bypassing preleasedg by Drosha (Okamura ethrough007; Ruby et al, 2007).
What happens if you completely bypass protein processing?
Basically, if you interfere with or bypass protein processing, you alter the immune response to proteins.
Research (Raichle, 1998; McCrone, 1999) has shown that once the brain is familiar with a linguistic task, it is able to bypass the processing route that was used to learn it (Wray & Perkins, 2000).
Mirtrons bypass Drosha processing, and instead use mRNA splicing machinery to generate pre-miRs [ 15].
Alternately, the transgenic overexpression of CRD-Nrg1 might bypass the processing by Bace1.
A subset of intronic miRNAs, known as mirtrons, bypass Drosha processing and are spliced from the intron [ 16- 18].
Two of the miRNA candidates were classified as mirtrons (intronic miRNA precursors that bypass Drosha processing) [ 33- 35].
Besides this canonical pathway, intronic miRNA precursors that bypass Drosha processing have been discovered, first in Drosophila melanogaster and Caenorhabditis elegans [ 41] and later in mammals [ 42].
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