Sentence examples for bypass lethality from inspiring English sources

Thus, reduction in Lpp mediated by overexpression of SlrA sRNA or loss of lpp can bypass lethality, when the LPS synthesis is increased due to accumulation of LpxC.

To bypass lethality, conditional models have been extensively used to study Fancd1 tumour suppressor function and have revealed a synergistic effect of combined Fancd1 and p53 deficiency on tumorigenesis (Jonkers et al., 2001).

Because mir-35 -41 deletion mutants can bypass embryonic lethality at 15° or 20°, postembryonic phenotypes have also been characterized for animals that escape lethality at these permissive temperatures.

In yeast, NR supplementation can bypass the lethality of deletion of glutamine-dependent NAD+ synthetase, QNS1, [8] and extend replicative lifespan [9].

Results that smc3Q fails to bypass ctf7 ctf18 lethality suggest that Ctf18-RFC promotes cohesion in a fashion separate from Ctf7-dependent acetylation of Smc3.

To confirm that our transgenic animals were a good model for the post-developmental effects of RHO-1 we looked to see if altering RHO-1 signaling in adults using our heat shock-inducible transgenes could bypass this lethality.

To bypass embryonic lethality of Txnrd1 and Txnrd2 null embryos [16], [17], we used the Nestin-Cre (NesCre) transgenic mouse line, which targets precursor cells of the neuronal and glial lineage, thus achieving efficient gene deletion in both cell types [18], [19].

Inactivation or deletion of Wpl1 allows bypass of lethality associated with the eco1-1 alleles.

Wapl shows homology to the budding yeast Rad61 protein (Game et al, 2003; Warren et al, 2004) which, when mutated, allows bypass of lethality associated with Eco1 inactivation (Ben-Shahar et al, 2008; Unal et al, 2008).

This strategy allowed us to bypass the lethality of homozygous knockouts and create a novel Tsc2-based model of TSC that recapitulates many features of the human disease in the brain.

The implementation of genetic strategies to bypass embryonic lethality in Sucla2 mutants should allow the recovery and study of adult animals with global or tissue-specific Sucla2 deficiency to provide additional insights into disease pathogenesis and mtDNA biology.