Reduction of bypass duration or elimination of CPB, like it is performed in minimally invasive coronary bypass grafting, may be beneficial for patients and may further reduce the risk of SIRS.
Measurements and Main Results: Increased age and preoperative creatinine level, low body surface area, preoperative hematocrit, nonelective surgery, lower temperature on bypass, and duration of bypass were associated with an increased risk of transfusion of >2 U of PRBCs.
Factors independently associated with hyperlactatemia were the preoperative serum creatinine value, the presence of active endocarditis, the cardiopulmonary bypass duration, the lowest oxygen delivery during cardiopulmonary bypass, and the peak blood glucose level.
In a prospective study, the group of 35 adult patients (mean age 68 years) scheduled for cardiac surgery with standard cardiopulmonary bypass (duration 80 ± 30 minutes, heparin dose 3 mg/kg, mild hypothermia about 34°C) was evaluated.
The ability to correlate alterations in platelet function with the duration of bypass and early postoperative blood loss, however, has remained elusive.
These differences remained significant (p = 0.045) using logistic regression adjusted for age, gender and duration of bypass (Table 3).
However, patients had different clinical courses and heterogeneity would be expected, given the differences in age, type of operation and duration of bypass.
The cardiopulmonary bypass (CPB) time and duration of the surgery was significantly longer in patients who developed AKI (P = 0.024, P = 0.002).
These differences remained significant (p = 0.012) using logistic regression adjusted for age, gender, duration of bypass and baseline organ function (ejection fraction, diabetes, renal dysfunction; Table 2).
Research assistants were present in the operating room and recorded all events (e.g., blood pressures, duration of cardiopulmonary bypass and number of bypass grafts).
