Sentence examples for bypass activities from inspiring English sources

This type of analysis has permitted us to learn about the intricacies of in vivo DinB lesion bypass activities.

Thrombin generation has been investigated as a means to monitor treatment with bypassing agents such as factor VIII inhibitor bypass activity (FEIBA), which is an activated PCC, and recombinant factor VIIa in haemophilia patients with inhibitors.

However, the bypass activity of polκ with cisplatin lesions has not been well characterized.

Given concerns regarding adverse effects of blood product transfusion and limited efficacy of current antifibrinolytics, procoagulant medications, including recombinant factor VIIa (rFVIIa) and factor eight inhibitor bypass activity (FEIBA), increasingly have been used in managing refractory bleeding.

Thus, the relevance of different catalytic residues for bypass activity is likely to be lesion dependent.

We investigated whether changing the aromatic triad residues to different aromatic residues compromised the bypass activity of E. coli DinB.

We found that abasic bypass activity was dramatically decreased in NEs without FANCD2, compared to the NE carrying FANCD2 (Fig 4B).

Recently, interest in pol λ has been sparked by the observation that its error-free lesion bypass activity for the oxidized base 8-oxoguanine (8-oxodG) was strongly increased by the auxiliary factors PCNA and RPA [6], [7].

In the past decade, numerous DNA polymerases (pols) have been discovered that possess lesion bypass activity.

When heterologous boundaries are used to replace Fab-7 in BX-C, they are unable to provide bypass activity, while their insulating activity can be lost in a stage and tissue specific fashion (Hogga et al., 2001).

It has been suggested that pol λ is involved in translesion synthesis of abasic sites and 8-oxodG lesions, and that DNA polymerase δ-interacting protein 2 (PolDIP2) stimulates the 8-oxodG bypass activity of pol λ.