To this end, earlier reports have examined the 8-oxodG bypass abilities of hPolη, hPolκ, hPolι, and hRev1 separately by using various enzymatic assays.
Additionally, DNA polymerase IV (Dpo4) from thermophilic archaeon Sulfolobus solfataricus has been considered as a model Y-family enzyme because of its high expression levels in E. coli, its ease of purification, its high thermostability, bypass abilities similar to those of hpol η, and the fact that it is the only Y-family DNA polymerase encoded by S. solfataricus.
An agent must not have acquired her values and principles (and then be forced to sustain them) by means that bypassed her ability to evaluate them.
In this way, the development of more human-like machines stands at odds with the idea of technological singularity — a hypothetical moment posited by some futurists when super-intelligent machines will bypass human abilities and change civilization beyond what our piddling meat brains could ever imagine.
Complications of TIPS for treatment of HRS include the worsening of hepatic encephalopathy (as the procedure involves the forced creation of a porto-systemic shunt, effectively bypassing the ability of the liver to clear toxins), inability to achieve adequate reduction in portal pressure, and bleeding.
Thus, the results strongly demonstrate that in addition to the significant role of the stereospecificity, sequence context (N- ras codon dA-61 or dG-12), and DNA position (minor or major groove) of these bulky adducts on bypass efficiency, the ability to bypass a lesion can be enhanced with gapped DNA and depends on specific polymerase interactions in the DNA minor groove.
Because both hFb and hUASMC express DcRs, we decided to bypass their potential ability to compete for TRAIL by selectively activating DR5 using an agonistic antibody (LBY135, Novartis, Figure 1e).
These are often community hospitals that lack cardiac catheterization and revascularization (percutaneous coronary intervention [PCI] and coronary artery bypass grafting [CABG]) abilities.
Kevin Draper: Uruguay doesn't seem particularly confident in their ability to bypass the French midfield.
Emoji is now the fastest-growing language in history, thanks to its ability to bypass international barriers.
