In trials 1 and 2 only, calves were fitted with rumen cannulas by wk 2 of life.
Calves (n = 12; 3/treatment) in trial 1 were fitted with a rumen cannula by wk 2 of age.
While skin lesion scores did not differ at wk 1, by wk 13 lesion scores for several regions of the head, face, body, feet and legs were higher in G than S animals (P < 0.05).
Moreover, SCC and CC grafts displayed biocompatibility and integration with host corneal tissue after rabbit intra-corneal stromal transplantation by wk 6 under slit lamp microscopy, in vivo confocal microscopy and histological examination.
By wk 3 and wk 5 however, cortical volume decreases are widespread in the ipsilateral hemisphere.
Intriguingly, DBM analysis also suggests volume decreases in the contralateral CTX by wk 5.
By wk 5, DHT was no more effective than vehicle at reducing ILs.
Notably, in all three tests, functional impairment in lesioned animals was maximal by wk 1 post-lesion.
Post-mortem analyses of nigrostriatal integrity demonstrated that nigrostriatal destruction was already maximal by wk 1 in lesioned animals with no further increase at 3 or 5 wks.
By wk 3, both the ipsilateral VM and ipsilateral STR volume in addition to ipsilateral CTX volume were associated with changes in WBV.
