This notion of inflammatory induction of fascin expression in the epithelium is supported here by the widespread expression of fascin in tissue resected from patients with IBD.
By contrast, widespread expression of the neural transcription factor gene sox2 was not appreciably altered at 12 hpf, demonstrating that at this early stage, the reduced expression of ascl1b, neurod4, neurod, dlb and lhx9 in Hdac1-deficient embryos is not due to reduction in the pool of neural precursors, but rather the result of a failure to specify particular neuronal identities.
The unique role of TRAIL death receptors in the nervous system is highlighted by the widespread expression of DR4 and DR5 in many cell types in the human brain, including neurons, astrocytes, oligodendrocytes, and EC, as well as by DR5 overexpression in AD.
The Src family members Src, Fyn, and Yes in mammals, as well as Src42A and Src64B in Drosophila, are widely, even ubiquitously expressed, and kept in check partly by the similarly widespread expression of Csk (Takahashi et al., 1996; Tateno et al., 2000; Takahashi et al., 2005; Wheeler et al., 2009).
Expression of GFAP and IBA1 increased with age and, by 34 weeks, there was a widespread expression of GFAP and IBA1 in the spinal cord of SOD1 G93Adl B6 mice, indicating advanced astroglial and microglial reactions (Fig. 6).
In AD brains, widespread expression of CD40 by microglia has been observed; however, it was noted that increased microglial CD40 expression was only prominent in AD brains with other disease factors such as bacterial encephalitis [ 17].
Manitt, C. et al. Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cord.
This reduction could not be consistently confirmed by immunoblot analysis, perhaps because of the widespread expression of β-catenin in different cell types within the hippocampus (Figure 1C).
