Successive drafts of a narrative that described the themes seen in the findings were then discussed by the wider study group (RB, BC, JL, RR) and further refined.
2 This observation appears to be supported by a wider study of European countries which also demonstrated lower cancer survival in those with primary care-based gatekeeper systems.
In yeast, the overall importance of Puf3p for mitochondria has been highlighted by genome-wide studies, which have identified 220 putative Puf3p-associated transcripts [17].
The availability of densely spaced SNPs generated by genome-wide studies has also enabled the investigation of genome structural variations, such as copy number variants (CNVs).
Those regions or genes found only by genome-wide studies, including genome-wide association study, cytogenomic study, whole-exome sequencing, and next generation sequencing (NGS), are cited separately.
As suggested by genome-wide studies in Drosophila and fungi, such divergence in evolutionary patterns may indicate differences in functional essentiality [ 36, 37].
The population structure by genome-wide studies (Xu et al. 2009; Chen et al. 2009) highlighted the importance of correction for population stratification in genetic association study of Han Chinese.
For the loci suggested by genome-wide studies, we selected those genes, which were situated ± 3 Mb from the chromosome marker (single nucleotide polymorphism (SNP)) with the highest LOD score (Table. 5).
CpG_2 (Chr 19: 16861552; NCBI build 36.1/hg18) equals cg03636183, the locus identified to be differentially methylated according to smoking exposure by genome-wide studies (Breitling et al. 2011; Shenker et al. 2013; Wan et al. 2012).
The incipient state of knowledge on the evolution of gymnosperm gene families would surely be enhanced by genome-wide studies that include analyses of gene expression data and sequence divergence in gene families of several species.
