Sentence examples for by wider changes in from inspiring English sources

These have been predominantly driven by wider changes in society namely the computer, internet and globalisation.

These factors in turn are influenced by wider changes in government operations within and beyond the health sector.

Expression of different levels of CD105 by tumours is associated with wider changes in gene expression, allowing the identification of novel genes not previously implicated in CNS tumour angiogenesis.

Tissue differentiation is accompanied by genome-wide changes in the underlying chromatin structure and dynamics, or epigenome.

Primary CRC can be divided into two main groups, firstly tumors with chromosome instability (CIN) showing high rates of chromosome losses and gains and secondly tumors with microsatellite instability (MSI) characterized by genome-wide changes in repetitive sequences due to defects in the DNA mismatch repair system [ 20].

Here, we investigate the role of Tip60 HAT activity in transcriptional control during multicellular development in vivo by examining genome-wide changes in gene expression in a Drosophila model system specifically depleted for endogenous dTip60 HAT function.

Here, we investigate the role of Tip60 HAT function in transcriptional control during multicellular development in vivo by examining genome-wide changes in gene expression in a Drosophila model system specifically depleted for endogenous dTip60 HAT function.

1 This phenomenon is largely driven by complex, population-wide changes in demographic, social and economic status, with associated changes in lifestyle habits.

This study provides a concrete example of how the Epigenome Project supports the understanding of the progression from nonaggressive breast cancer to metastatic cancer by establishing genome-wide changes in epigenetic marks, at least in part through global reorganization of higher order chromatin structures by proteins such as SATB1 and others.

Support for the predicted pathways is provided by analysis of genome-wide changes in transcript levels by DNA microarray in cells oxidizing benzoate.

To test how the pattern of expressed microRNAs is affected by replicative senescence, we studied transcriptome-wide changes in microRNAs using miRNome arrays (not shown); we then validated individual microRNAs by reverse transcription (RT) followed by real-time, quantitative (q PCR amplification (see Materials and Methods).