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(4-Ethyl-piperaz-1-yl)-phenylmethanone 4-Ethyl-piperaz-1-yl -phenylmethanonethat glutamate displayed on PC12 cells, suggesting that the reduction of glutamate-induced neurotoxicity may be one of the mechanisms by which this compound exerts its neuroprotective properties against the deleterious effects of the Aβ1–4-Ethyl-piperaz-1-yl -phenylmethanone
The mechanism by which this compound induces apoptosis has not been identified.
The mechanism by which this compound promotes cell dedifferentiation, however, is unknown and will likely be difficult to decipher.
Although many studies have shown that pinocembrin possess various biological properties, the mechanisms by which this compound acts against cancers remain unclear.
The X-ray crystal structure of this compound with Cdk2 has been reported, and has revealed the mechanisms by which this compound interacts with the Cdk2 ATP binding site (Misra et al, 2004).
Although the excess endogenous production of PGE2 appears to be associated with the induction of RA FLS death, the exact mechanism by which this compound brings about this phenomenon remains to be elucidated.
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Based upon the results obtained, oxidation mechanisms were proposed with the objective of highlighting important aspects of structure activity relationships and understanding the unexplored pathways by which this class of compounds exert its biochemical actions.
This study found that PDTC decreases the proliferation of immortalized human ADPKD cells, suggesting that this may be the mechanism of action by which the compound decreases cyst growth in experimental PKD [ 16].
The antiviral activity of ribavirin was reported almost four decades ago, but the molecular mechanism by which the compound exerts its antiviral activity still remains a matter of debate.
To evaluate the compounds for their target and the mechanism by which the compound affects JAK enzyme activity, the compounds were tested against JAK family kinases (JAK1, JAK2, JAK3, and Tyk2) with the Caliper microfluidic mobility-shift platform.
The mechanism by which these compounds pass from the mother's blood to the milk is not fully understood.
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