Sentence examples for by which the mutant from inspiring English sources

However, the mechanisms by which the mutant proteins exert these functions remain to be identified.

All three models are mutually compatible, which might explain why it has been challenging to determine the exact mechanism by which the mutant lamins cause muscle disease.

In summary, the N17 domain of huntingtin is a multifunctional localization signal that regulates the subcellular localization of huntingtin, is regulated by post-translational modification and contributes to the pathogenic mechanism by which the mutant protein causes disease.

The mechanism by which the mutant band 3 failed to access or remain in the membrane, either in the erythrocytes or in the α-intercalated cells, was not elucidated, although a recent report shows that the Val488Met band 3 mutant is retained intracellularly when expressed in Madin-Darby canine kidney (MDCK) cells.

Thus, the mutants provide a range of activities both above and below wild-type that can be seen in both experimental modes, and the mechanism by which the mutants stimulate branch formation appears to be identical to wild-type.

The present study was designed to address the mechanism by which the LQT9-causing mutant Cav3-F97C affecthethe function of caveolar SCN5A.

Using a related type of assay, the ATP-mediated rescue assay, we compared the rates by which the WT and mutant RTs unblock TFV-terminated primers and extend products past the point of chain-termination.

To investigate the mechanism by which the Hxk2 wca mutant protein signals glucose repression in the W303.1Awca strain and the loss-of-repressing function in the W303.1Awrf strain, we performed two-hybrid, co-immunoprecipitation and GST pull-down experiments.

To identify a potential mechanism by which the catalytically inactive mutants of UBE3A inhibit S5a function, we monitored their effects on the levels of S5a ubiquitination.

Applying multiple analytic approaches, we describe a novel mechanism by which the deleterious consequences of mutant COMP retention results in upregulation of miR-223 disturbing the adipogenesis - osteogenesis balance.

This supports the idea that the mechanism by which the klp10A knockdown and mutant cause elongated spindles does not involve a change in microtubule growth rates, but rather a decrease in microtubule disassembly, as expected from the microtubule depolymerization activity of kinesin-13 proteins in vitro.