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Thus, an important future goal will be to pursue structural studies of these interactions, as they have the prospect of uncovering different ways by which the function of coatomer is regulated.
Within the life of an animal the pathways are regulated by all the mechanisms by which the function of a gene product may be regulated: gene expression, post-translational modification, subcellular location, and so on.
In addition to promoter methylations or mutations, LOH resulting from a deletion spanning one or more genes is one of the mechanisms by which the function of genes is lost.
Since anergy is one of the mechanisms by which the function of autoreactive B cells can be downregulated, a comparison of the productive B-cell repertoires of CD19loIgD+ and CD19hiIgD+ subsets from the same lupus patient was undertaken to determine whether the anergic B cells were oligoclonal or otherwise enriched in cells expressing genes known to encode autoantibodies.
Coupled to this, it would be advantageous to have a means by which the function of a gene could be attenuated but without complete loss of function, such as virus-induced gene silencing, and the ability to regulate genes driven by a set of highly controllable promoters by which gene expression can be predictably controlled (Kilaru et al., 2015c; Lebrun et al., 2015; Lee et al., 2015).
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Thirdly, in view of the current debate related to the functional relevance and specificity of brain's default network, they reveal a novel approach by which the functions of this network can be further explored.
In the DDC model, subfunctionalization is the process by which the functions of the ancestral gene are subdivided between the duplicated genes.
Biofuels, in the form of organic solvents, are inserted in the membrane or passed through the membrane, by which the functions of the cell membrane are collapsed.
Despite the fact that these subunits are interchangeable (Phelan et al, 1999), the mechanism by which the functions of BRG1 and BRM are distinguished in the SWI/SNF complex is currently poorly understood.
We now demonstrate that this variant is frequently over-expressed in cervical SCC and this may, at least in part, be the basis by which the functions of full-length p73α are nullified in such cases.
Potential mechanisms by which the 'barrier function' might become flawed, such as mossy fiber sprouting, are discussed.
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