Sentence examples for by which substrates from inspiring English sources
In order to obtain a clearer understanding of the fashion by which substrates and inhibitors bind to tyrosinase, we have determined dissociation constants (KD) between TyrBm and its substrates or inhibitors using MicroScale Thermophoresis34.
Each catalytic step of every reaction sequence in MACiE is fully annotated so that it includes the function of the catalytic residues involved in the reaction and the mechanism by which substrates are transformed into products.
Some of the primary mechanisms are long-range allosteric interactions by which substrates in one part of the biochemical network affect the activity of enzymes at distant locations in the network (not distant in the cell).
However, the mechanism by which substrates are targeted for autophagic degradation is unknown [20].
The mechanism by which substrates are released from cortex, and in particular the role of multisite phosphorylation, has been unclear, however.
The melting of this helix is thought provide the route by which substrates enter and products depart the active site (6).
The manner by which substrate passes through the transporter (the 'hatch-barrel problem') is currently unknown.
However, the mechanism by which substrate stiffness regulates a neural network activity, and the importance of ECM composition in conferring substrate stiffness sensing have not been explored.
Conservation of the groove fold suggests a common substrate-binding mechanism, while the absence of residue conservation in this region across the kinase family suggests the means by which substrate specificity is determined.
Although the key to their catalytic cycle is the fact that binding and positioning of primary substrate precede O2 activation, the means by which substrate binding stimulates turnover is not well understood.
As the consensus chemical mechanism is an ordered sequential one, with O2 reacting at the Fe prior to oxidation of the primary substrate (Scheme 1), identifying features of the active site by which substrate binding stimulates O2 reactivity is crucial to understanding the chemistry of this superfamily.
