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Finally, the 1b up-regulation of p21 expression and apoptosis induction seem to be the mechanisms by which it promotes its anti-leukemic effects, making this new molecular architecture a promising prototype for leukemia intervention.
The mechanisms by which it promotes fibrosis are not entirely elucidated, however in addition to inhibiting protease activity in the extracellular compartment, it may modulate inflammatory cell recruitment, and fibroblast activation [47].
While bacterial dysbiosis has been associated with CRC, the mechanism by which it promotes colon carcinogenesis has not been elucidated.
In this way, IGF-1 enhances proliferation as well as terminal differentiation, by which it promotes nucleus condensation and enucleation [ 3].
The adaptor molecule Lnk/SH2B has been implicated in IIS but the mechanism by which it promotes IIS activity has remained enigmatic.
In addition, IL-6 alone, without the need of TGFβ, induces IL-21 expression, a mechanism by which it promotes the generation of follicular T helper (Tfh) cells (Nurieva et al., 2008; Suto et al., 2008; Dienz et al., 2009; Diehl et al., 2012).
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Such evaluation should not only include the success of taking of such substitute or the rate by which it promoted healing but also through assessing the function and the durability of such substitutes.
HIF1α was recently identified as a potent regulator of ALDC, another mechanism by which it may promote carcinogenesis.
The mechanism by which ID2 promotes lung tumor progression is not clear yet.
This domain provides an E3 ubiquitin ligase activity to the proteins by virtue of which, it can promote attachment of monomeric ubiquitin or ubiquitin chains of various kinds to the substrate.
The Pink Brick Box was also criticised by Pink Stinks in the UK, which said it promotes stereotypes.
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