Sentence examples for by which it mediates from inspiring English sources

Our study clearly demonstrated that PC selectively targets MAPK signaling pathway and it also altered the expression of proteins involved in cell cycle and cell survival by which it mediates its growth inhibitory and apoptosis.

HRG has been studied to identify mechanisms by which it mediates anti-tumor effects; and the results revealed that TAMs activated by HRG down regulated expression of pro-angiogenic cytokines and upregulated that of angiostatic cytokines.

Although riluzole shows efficacy in ALS, the mechanism by which it mediates neuroprotection is still unclear.

Mechanisms that have been implicated in driving diabetic cardiomyopathy include hyperinsulinemia, which acts to stimulate PI3Ka/Akt-1 pathways by which it mediates glucose uptake [ 33].

A previous study showed that high dose of ALA reduces body weight in obese humans [ 18], ALA treatment is associated with body fat loss, which it mediates by suppressing AMPK activity in the hypothalamus [ 19].

Finally, one must allow for a considerable Egyptian and western Semitic influence on Archaic Greek religion, political organization, and thought, though its precise extent and the means by which it was mediated await proper scientific treatment.

Since the decoction comprised of Nigella sativa seeds, Hemidesmus indicus roots and Smilax glabra rhizomes has been demonstrated experimentally to possess anti-hepatocarcinogenic properties [ 1, 2], for further development of this decoction for the treatment of human HCC, it is important to investigate whether apoptosis is also a major mechanism by which it can mediate anticarcinogenic effects.

CaM is known to be able to localize in either nucleus or cytoplasm in various tissues including the testis [ 15]; the exact mechanism by which it mediates/contributes to SRY nuclear import remains to be determined, but one possibility is that CaM facilitates nuclear import through mediating direct interaction of SRY with the NPC.

For instance, to advise public health action, it may be important to break down the effect of E on O by the extent to which it is mediated through D. The size of such mediation can be measured as the relative change in the RR associated with E when estimated from models including and excluding, respectively, D as a covariate.

The extent to which genetic susceptibility to breast cancer in mutation carriers and in the general population is shared, as well as the extent to which it is mediated by ER status, need to be quantified systematically by future studies.

Further, the molecular mechanisms by which IGF1 mediates its prosurvival properties in melanoma cells remain unknown.