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Although Aβ unquestionably plays a causative role in AD, the underlying mechanisms by which it contributes to the development of this disease are still controversial.
The functionality of the T6SS encoded in SPI-19, as well as the molecular mechanisms by which it contributes to Salmonella pathogenesis and host-specificity, are currently under study in our laboratory.
We first set out to characterize the structure of C. elegans SAS-6 to uncover the mechanisms by which it contributes to centriole formation.
Despite the importance of SH protein in the HRSV life cycle, the mechanism by which it contributes to virulence remain unclear.
This study examines the operation of health post supervision in rural districts of Guatemala in order to understand the mechanisms by which it contributes to the performance of auxiliary nurses, a cadre of MLHWs.
2, 3 Although a link between oxidative stress and neurodegeneration has long been suggested, the mechanism(s) by which it contributes to pathogenesis in specific neurodegenerative diseases has not been clearly elucidated.
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It is argued that in addition to being causative and descriptive, a program must also be rationally justifiable, i.e., the specific structure of the program should be explainable by the (rational) ways in which it contributes to achieving the intended goal.
The regulation of lif expression by N-Myc is a mechanism by which it may contribute to neuroblastoma genesis but also ESC and iPSC biology.
Our demonstration that CX3CL1 has a robust antiapoptotic effect on human monocytes suggests a direct means by which it could contribute to atherosclerosis.
Together these data suggest Myc regulation of stem-related factors is an important mechanism by which it controls stem cell function and contributes to tumorigenesis.
CaM is known to be able to localize in either nucleus or cytoplasm in various tissues including the testis [ 15]; the exact mechanism by which it mediates/contributes to SRY nuclear import remains to be determined, but one possibility is that CaM facilitates nuclear import through mediating direct interaction of SRY with the NPC.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com