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We propose a simple model by which conformational changes in H and R helices mediate CLH-3b regulation by activation domain phosphorylation.
These authors proposed a mechanism by which conformational changes in the C-terminal cytosolic tail of Ctr1 lead to inhibition of the Ctr1-mediated copper uptake [16].
(C ) Schematic model of the mechanism by which conformational changes in the D2 and TMHs are coordinated.
These domains are known to be a homodimeric assembly adopting a parallel four-helix bundle (Hulko et al., 2006; Ferris et al., 2011), although the exact mechanism by which conformational changes are propagated through a signaling protein via HAMP domains remains a topic of great interest (Swain and Falke, 2007; Zhou et al., 2009; Ames et al., 2014).
Indeed, by assigning a continuous and extended density to TraF/VirB10NT within the IL, we can now map out the entire TraF/VirB10 structure and thus identify an uninterrupted path by which conformational changes would need to be relayed to reach out to the OM components.
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Transport mediated by ABC proteins is an energy-dependent event, during which conformational changes are transmitted between the NBDs and the TM domains.
This limits the extent to which conformational changes can be dissipated locally, causing their transmission over long distances.
We show how variable free myosin is a selective advantage for activating the muscle and describe a mechanism by which a conformational change in tropomyosin propagates free myosin given constant total myosin.
Following budding, HIV maturation is initiated by proteolytic processing of Gag, which induces conformational changes in the CA domain and results in the assembly of the distinctive conical capsid.
Surface concentration changes of charged species can be induced by applying an electrochemical potential which generates conformational changes of probe molecules.
AKT kinase activity is suppressed following DC120 treatment, but AKT (Ser473) is phosphorylated by mTORC2, by which the above conformational change by the inhibitor itself contributes to the process, leading to the phosphorylation of AKT (Thr308).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com