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Moreover, molecular dynamics simulations have identified an allosteric mechanism by which binding of palinurin leads to GSK-3β inhibition.
The precise mechanism by which binding of tumor necrosis factor ligands to the extracellular domain of their corresponding receptors transmits signals across the plasma membrane has remained elusive.
(2007) describe a mechanism by which binding of Ydj1 to Ssa1 promotes release of Cln3.
Does this observation question the molecular mechanism by which binding of syntaxin-1A produces changes in channel gating?
Despite recent molecular reconstructions from low resolution (25 Å) electron microscopy of a TOR1 Kog1 subcomplex (Adami et al. 2007), the molecular mechanism by which binding of FKBP-rapamycin inhibits TORC1 activity is enigmatic and remains a fascinating question.
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The molecular mechanisms by which the binding of the Sir proteins and the establishment of a silenced local chromatin domain repress transcription are the subject of this study.
On the other hand, the molecular mechanisms by which the binding of a toxin, or simple changes in chloride concentrations, induce such functional changes remain elusive.
The exact cellular and molecular mechanism by which the binding of anti-CD20 monoclonal antibodies to B cells induces cell death is not fully understood [ 18].
We describe a new serine protease inhibition motif in which binding is mediated by a cluster of very short hydrogen bonds (<2.3 Å) at the active site.
Conformational plasticity may be one mechanism by which the binding affinity of a CYP and its redox partner are modulated: if the subset of conformational states occupied by the reduced electron transfer protein is the same as that selected upon binding to a cognate CYP, then the entropic cost (i.e., free energy) of binding would be lowered, resulting in a higher affinity.
Elucidation of the molecular mechanisms by which PGZ binding provokes disassembly of complex I requires further studies.
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