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The entry of sucrose into different utilization pathways is regulated by various isoforms of invertases (Sturm 1999).
For external validation, we used an evaluation set of 22 drugs that are transformed to active metabolites by various isoforms of cytochromes P450.
The metabolism of AA by various isoforms of COX (cyclo-oxygenase) generates lipid products that can increase insulin secretion [ 16].
All three receptors can be used by various isoforms of the various genes to signal to increase vascular permeability, angiogenesis, and other actions of VEGFs.
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Some of the conflicting evidence might be explained by the various isoforms of HER4 [ 41] or by the inherent difficulty of separating HER4 responses from those of the other family members.
Similar findings (i.e. attenuation of pulmonary dysfunction) have been described by our group and others by using inhibitors of various isoforms of NOS on different ovine models of acute lung injury [ 25, 32- 34].
This conundrum may be explained in part either by selective inhibition of the various isoforms of NOS or by an ancillary non-vascular function of NOS.
Data collected within the last five years point to an intriguing association between the alkylation activity of methyl bromide (which is modulated by the expression of various isoforms of GST) and the development of prostate cancer.
Cyclic AMP is formed from adenosine triphosphate by the action of various isoforms of the enzyme adenylyl cyclase (AC), each of which is specifically regulated by G proteins, calcium, and other modulators (1).
In other words, more than one isoforms of these genes displayed differential expression between non-oncogenic and cancer samples, but the gene-level expression differences were cancelled out by the combined effect of various isoforms of the same gene.
For instance, its potency to inhibit COX-2 in the nanomolar range has been eclipsed by its ability to inhibit various isoforms of carbonic anhydrase (CA) at even lower concentrations (see below).
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