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Even though IUP is usually considered in litter-bearing mammals where fetuses are influenced by variable levels of steroids (androgens and/or estrogens) due to the sex of neighboring fetuses, a similar situation can be found in dizygotic (DZ) twins indicating that humans are also sensitive to steroid influences by the neighboring embryo.
We note that determination of dephosphorylation kinetics in certain preparations of Maf1 was prevented by variable levels of a contaminating protease.
Despite being connected by variable levels of gene flow, these populations can indeed follow semi-independent adaptive evolutionary trajectories shaped by selection by their local environments.
This is consistent with the islet heterogeneity in the nulls demonstrated by variable levels of NKX6.1, PDX1 and C-PEP immunostaining (ESM Fig. 4 e h).
This was accompanied by variable levels of C-PEP immunofluorescence in the Aldh1b1tm1lacZ null P1 pancreases, where 50% of the islets had either reduced or absent staining compared with controls (ESM Fig. 2c, d, d').
Detailed, quantitative pyrosequencing analysis of genomic DNA from this series revealed that methylation in the CpG island of CACNA2D3 was heterogeneous within individual cancers, as evidenced by variable levels of methylation at specific CpG dinucleotides within the analysed fragment.
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Previous studies have demonstrated that some genes were characterized by their variable levels of methylation in different tissues, and undermethylation in these genes in general correlated with tissue-specific gene expression [16], [41], [42].
By contrast, variable levels of NORE1 transcripts were observed in cancer cell lines.
Meta-population dynamics can therefore be distinguished from island dynamics by low, variable levels of migration among populations.
We perform these simulations by using variable levels of recombination to determine the limitations of six well-established indirect tests of recombination.
Such dynamic fluorescence display often reported throughout development in amphioxus is clearly supported here by the variable levels of expression for different GFPs (Fig. 2).
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