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The analysis of Fh and Fg indicates that the large variability in bioavailability of sirolimus could be explained in large part by variable expression of intestinal CYP3A due to the relatively high contribution of intestinal metabolisms reflected by Fg value of 0.16.
Collectively, gene and protein analyses indicate that several inductive signals (PDGFBB, or RA or EGM-2 basal medium) are able to drive the SMC differentiation of CD34+ or CD34+KDR− cells, characterized by variable expression of SMC proteins and minimal assembly of the α-SMA protein into filaments.
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Indeed, different states of MSC activation are relayed by variable expression levels of certain miR including miR-335.
Additionally, cell to cell variations in the kinetic parameters, e.g. induced by variable expression levels of the enzymes, are important.
HNSCC lesions were indeed found to exhibit a widely aberrant PG expression pattern characterized by a variable expression of all PGs and a characteristic de novo transcription/translation of GPC2, GPC5 and NG2/CSPG4 respectively in 36%, 72%and71%1% on 119 cases.
This syndrome is characterized by a highly variable expression of phenotype, ranging from discreet to quite strong.
A coefficient computed by this method for each variable expression of "predictor" genes indicates the direction and degree of flexing that the predictor has on the TTR curve.
We analyzed the presence of all AQP transcripts in 576 different normal lung and non-small cell lung cancer (NSCLC) samples using microarray data and validated our findings by qRT-PCR and immunohistochemistry. Variable expression of several AQPs (AQP1, -3, -4, and -5) was found in NSCLC and normal lung tissues.
In fact, quite variable expression of transgenes driven by the minimal rat probasin promoter, as well as larger promoter fragments, have been reported upon previously [82].
Variable expression of these proteins may be a major mechanism by which M. bovis evades the host immune response.
Variable expression of these proteins may be a major mechanism by which M. bovis evades the immune response [ 1].
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