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Additionally, cell to cell variations in the kinetic parameters, e.g. induced by variable expression levels of the enzymes, are important.
Indeed, different states of MSC activation are relayed by variable expression levels of certain miR including miR-335.
While an increase in basal activity of the γ2 mutations has been previously proposed, this was either based on indirect assays after expression in yeast (Arad et al., 2002) or on kinase assays after transient transfection, which is complicated by variable expression levels (Burwinkel et al., 2005).
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The MGMT status in pituitary adenomas has been evaluated in several previous studies by immunostaining, showing variable expression levels in different subtypes of pituitary adenomas [ 7, 8, 24, 31– 31].
However, 31 genes refuted that expectation by containing alternative promoters with variable expression levels (Figure 5B).
Genes with variable expression levels are Fkbp1b, Fkbp5, and Fkbp16.
However, Hspb5 (αB-crystallin) and Hspb7 show high levels of basal expression while µ-crystallin (crym) shows variable expression levels.
Rather, neurons with variable expression levels appear intermingled, and apically-located neurons generally display the highest levels of expression.
The specific binding of A10-2 to GP73 was also supported by the observation that several tumor cell lines exhibited variable expression level.
Observed variables are expression levels of genes measured by microarray experiments.
These changes were paralleled by increased expression levels of CD36.
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