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The model was built on the current understanding of the biochemical processes involved in HGF and H. pylori induced c-Met signal transduction and iteratively improved by validation with published experimental results.
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The validation step with published literature also provided insights about situations when proteins selected by the proposed procedure are not moonlighting, i.e. when proteins with distinct GO terms are not actually moonlighting.
Validation of the SOFC and absorption chiller models is performed by comparison with published data.
Model validation for both transversally and axially FGB was done, by comparing the obtained results with published ones.
Thus only partial validation is achieved, which is consistent with published results obtained with other flow solvers.
The comparison of shear stress and Nusselt number results with published correlations constitutes a partial validation of the CFD model.
A comparison with published two-dimensional BALF maps followed by immunoblotting validation identified the proteins corresponding to the remaining three spots with the aforementioned criteria (Table 4).
However, overall our findings were congruent with previously published results of prospective studies, providing external validation to the technology.
Validation is based on the material collected in a previous study [ 13], with published data from the right eye only.
Together with published data about potential effect of KLKs on ovarian cancer proliferation, these data strongly suggest that KLK10 is a candidate downstream target by which miRNA can affect ovarian cancer proliferation, although further experimental validation is required.
Validation of our analysis is made by comparing with a published porous-sphere experiment Raghavan et al. (2005) [6] which used methanol fuel.
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