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However, every individual is evaluated by utilizing the constrained-based discrete-event simulation.

The following theorem sharpens the upper bound of Grüss's covariance inequality (3.3) by utilizing the notion of quadrant dependence (cf. Lehmann [12]) and incorporating constrains on the means of random variables and (cf. Zitikis [6]).

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In the present paper we sharpen the upper bound of a Grüss-type covariance inequality by incorporating a notion of quadrant dependence between random variables and also utilizing the idea of constraining the means of the random variables.

Our derivation is based on extending the constrained maximum likelihood density based approach that is utilized in the univariate setting as an alternative strategy to the approach originally developed by Kaplan and Meier (1958).

To evaluate the rate of molecular evolution at each locus, standard likelihood ratio tests were performed on individual loci as in [21], utilizing the best-fit model and the same model constrained by clock assumptions.

The inverse problem is posed as a constrained optimization problem under regularization and solved utilizing the adjoint equations.

Cost management, on the other hand, is proactive in nature, and tracks anticipated cost from conception to construction, with adjustments along the way, to change the budget when necessary, or change the design when constrained by budget; and utilizes the discipline of value management to make good decisions in the best interest of all stakeholders.

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In our algorithm we utilize various constraining properties of features identified in the upstream and downstream regions around TSSs, as well as statistical analyses of these surrounding regions.

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