In our attempt to obtain further in vivo evidence of caspase-4 down-regulation mediated by an FE65/Teashirt complex, we encountered the difficulty that the CASP4 gene was not represented in the mouse genome (discussed further below), preventing us from utilizing mouse models of AD as well as knockout mice.
Utilizing mouse models provides excellent immunological and experimental tools to study oral immune responses.
Physiological studies utilizing mouse models have suggested that energy metabolic defect in adult muscle is interpreted by some cellular pathways as a state of starvation, despite normal nutrition, leading to "pseudo-starvation" response.
To utilize mouse models to further characterize the pathogenic mechanisms of airway remodeling and airway hyperresponsiveness in severe asthma.
Here, we have utilized mouse models bearing these lupus susceptibility loci to investigate the therapeutic potential of Btk in a spontaneous murine model of lupus nephritis by treating the mice with a small molecule Btk-inhibitor, PCI-32765; this is an irreversible inhibitor that binds covalently to Cys-481 of Btk with an IC50 of about 0.5 nM in biochemical assays.
Indeed, such a notion was supported by utilizing various mice models with altered Smad7 expression levels.
MicroRNA were initially reported to have a role in skeletal muscle development utilizing mouse, drosophila, and zebrafish models.
By utilizing genetically engineered mouse models of neurofibromatosis type 1 (NF1), we demonstrated that plexiform neurofibroma, the only benign peripheral nerve sheath tumor with potential for malignant transformation, results from Nf1 deficiency in fetal stem/progenitor cells of peripheral nerves.
All experiments utilizing mice were approved by the Institutional Animal Care and Use Committee IACUC Approval No.. 1001246) at National Yang-Ming UniversiTaipeiipei, Taiwan).
Recently, David et al. [ 117] utilizing the mouse model of anxiety/depressive-like state induced by chronic corticosterone treatment contributed to a better understanding of the link between antidepressants and hippocampal neurogenesis.
The reported experiments utilized mouse (mmu -miR-153 as an experimmu -miR-153.
